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Immunoblot ANA Strips

ANA-19s

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Cat No.:61000                                        ★Download Datasheet★
Size: 24 tests/box

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    Introduction

    Antinuclear antibodies (ANA) are a group of autoantibodies that specifically target substances in the nucleus of cells. One group of ANAs represent autoantibodies against extractable nuclear antigens, such as SS-A/Ro, SS-B/La, Sm, RNP, Scl-70 and Jo-1, which are mainly ribonucleoproteins and nuclear enzymes. Another group of ANAs are against nucleic acids (dsDNA), complexes of nuclear proteins and histones.

    Detection and classification of these ANAs in human blood are important for differential diagnosis of systemic autoimmune diseases (SAD). Utilization of high-quality autoantigens for the screening and semi-quantification of specific ANAs has been routinely used in clinical practice for precision diagnosis and monitoring the progression of these diseases.

    Assay Characteristics

    Autoantigens

    Clinical Indication

    dsDNA

    SLE (highly specific marker)

    Histones

    SLE; drug induced form of SLE; systemic sclerosis; rheumatoid arthritis

    SmB/B’ & SmD1 & SmD3

    SLE (highly specific marker)

    P0 & PCNA

    SLE

    snRNP A & C & 68/70 (snRNPs)

    MCTD (primarily isolated appearance); SLE; Sjogren’s syndrome; systemic
    sclerosis (combination with other antibodies)

    SSA/Ro52 & SSA/Ro60 & SSB/La

    Sjogren’s syndrome (primary, secondary); SLE (dermal forms LE);
    neonatal LE syndrom

    Jo-1

    DM/PM; increased risk of pulmonary fibrosis

    PL-7 & PL-12

    DM/PM; antisynthetase syndrome (myositis, interstitial pulmonary fibrosis,
    arthritis)

    PmScl-75

    DM/PM; systemic sclerosis

    CENP-A & CENP-B

    CREST syndrome; SSc (limited form without the appearance of antigen
    Scl-70)

    Scl-70

    SSc; overlap syndrome scleromyositis (highly specific marker)


    Unique Advantages

    ◆ Ready-to-use components;

    ◆ Simultaneous diagnosis of 7 major SADs in 1 test;

    ◆ Easy interpretation;

    ◆ Superior batch-to-batch reproducibility;

    ◆ Excellent specificity and sensitivity (> 95%);

    ◆ Rapid procedures (~ 35 minutes);

    ◆ Positive and negative controls;

    ◆ Strict quality control and clinical validation.