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Immunoblot ANA Strips

ANA-17s

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Cat No.:61001                                        ★Download Datasheet★

Size: 24 tests/box

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Introduction

Antinuclear antibodies (ANA) are a group of autoantibodies that specifically target substances in the nucleus of cells. One group of ANAs represent autoantibodies against extractable nuclear antigens, such as SS-A/Ro, SS-B/La, Sm, RNP, Scl-70 and Jo-1, which are mainly ribonucleoproteins and nuclear enzymes. Another group of ANAs are against nucleic acids (dsDNA), complexes of nuclear proteins and histones.

Detection and classification of these ANAs in human blood are important for differential diagnosis of systemic autoimmune diseases (SAD). Utilization of high-quality autoantigens for the screening and semi-quantification of specific ANAs has been routinely used in clinical practice for precision diagnosis and monitoring the progression of these diseases.

Assay Characteristics

Autoantigens

Clinical Indication

dsDNA

SLE (highly specific marker)

Histones

SLE; drug induced form of SLE; systemic sclerosis; rheumatoid arthritis

SmB/B’ & SmD1 & SmD3

SLE (highly specific marker)

P0 & PCNA

SLE

snRNP A & C & 68/70 (snRNPs)

MCTD (primarily isolated appearance); SLE; Sjogren’s syndrome; systemic
sclerosis (combination with other antibodies)

SSA/Ro52 & SSA/Ro60 & SSB/La

Sjogren’s syndrome (primary, secondary); SLE (dermal forms LE);
neonatal LE syndrom

Jo-1

DM/PM; increased risk of pulmonary fibrosis

PL-7 & PL-12

DM/PM; antisynthetase syndrome (myositis, interstitial pulmonary fibrosis,
arthritis)

PmScl-75

DM/PM; systemic sclerosis

CENP-A & CENP-B

CREST syndrome; SSc (limited form without the appearance of antigen
Scl-70)

Scl-70

SSc; overlap syndrome scleromyositis (highly specific marker)


Unique Advantages

◆ Ready-to-use components;

◆ Simultaneous diagnosis of 7 major SADs in 1 test;

◆ Easy interpretation;

◆ Superior batch-to-batch reproducibility;

◆ Excellent specificity and sensitivity (> 95%);

◆ Rapid procedures (~ 35 minutes);

◆ Positive and negative controls;

◆ Strict quality control and clinical validation.