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干燥综合征 (Sjøgrens Syndrome)

SSA/Ro52

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Cat. No.: 41590

Other Names: TRIM21, SSA/Ro52, Ro52

Species: Human

Size: 0.1mg

Origin: Recombinant

Tag: N-terminal 6xHis

Source: Spodoptera frugiperda Sf9

Purity: >85%


Introduction

Ro/SSA ribonucleoproteins are involved in RNA quality control and cellular stress response to UV irradiation, and comprise of a
single polypeptide and four small RNA molecules including the 52 kDa Ro protein. Ro/SSA interacts with autoantigens in patients
with Sjogren syndrome and systemic lupus erythematosus.

Immunological Function
As an autoantigen, SSA/Ro52 binds with IgG-type human auto-antibodies.

Amino Acid Sequence

MSYYHHHHHHDYDIPTTENLYFQGAASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGS
VCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHR
DHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQR
QLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRS
VCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYW
EVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAG
MVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY


Applications
Standard ELISA test, line/dot assay and microarray assay with positive/negative sera panels.

Formulation
Liquid in storage buffer (50mM Tris, 300-500mM NaCl, 10% Glycerol, Protease inhibitor, pH8.0).

Description

Expressed in insect Sf9 cells with a total of 499 AA.

Mw: 57.1 KDa (calculated).

N-terminal 6xHis-tag and TEV cleavage site, 25 extra AA (highlighted).

Recombinant antigen for research use or manufacturing only.

Storage
Store at –80°C. Avoid repeated freezing /thawing cycles.

Quality Control Test

BCA to determine quantity of the protein.

SDS PAGE to determine purity of the protein.