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自身免疫性肝炎&原发性胆汁性胆管 (AIH & PBC)

Gp210

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Cat. No.: 41A280

Other Names:   Gp210, Nup210

Species: Human

Size: 0.1mg

Origin: Recombinant

Tag: N-terminal 6xHis

Source: E.coli

Purity: >90%


Introduction
The nuclear pore complex(NPC) is a massive structure that extends across the nuclear envelope, forming a gateway that regulates
the flow of macromolecules between the nucleus and the cytoplasm. As a part of NPC, gp210 is detected with a prevalence of 26%in PBC and 4% in AIH.


Immunological Function
As an autoantigen, gp210 binds with IgG-type human auto-antibodies.

Amino Acid Sequence

MRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDRWGSENLYFQGATVCTPRDLAVPAALTPRASPGHSPHYFAASSPTSPNALPPARKASPPSGLWSPAYASHGGGGSGGGGSTVCTPRDLAVPAALTPRASPGHSPHYFAASSPTSPNALPPARKASPPSGLWSPAYASHGGGGSGGGGSTVCTPRDLAVPAALTPRASPGHSPHYFAASSPTSPNALPPARKASPPSGLWSPAYASH

Applications
Standard ELISA test, line/dot assay and microarray assay with positive/negative sera panels.

Formulation
Liquid in storage buffer (8M Urea, 10mM Tris, 50mM Na2HPO4, pH8.0).

Description

Expressed in E.coli cells with a total of 238 AA.

Mw: 24 KDa (calculated).

N-terminal 6xHis-tag and TEV cleavage site, 44 extra AA (highlighted).

Recombinant antigen for research use or manufacturing only.

Storage
Store at –20°C. Avoid repeated freezing /thawing cycles.

Quality Control Test

BCA to determine quantity of the protein.

SDS PAGE to determine purity of the protein.

Immunodot analysis to determine functionality of protein.