Polyclonal Antibody against Human FABP4
Size: 0.1 mg
Introduction
Fatty-acid binding protein 4 (FABP4), also termed adipocyte fatty-acid binding protein (A-FABP), or aP2, is a novel
adipocyte-expressed factor which accounted for ~6% of total cellular proteins. Several animal experiments suggested that FABP4
plays a key role in the link between obesity and various features of metabolic syndrome. Mice with targeted disruption of FABP4
accompany FABP5 almost completely to protect against diet-induced obesity, insulin resistance, dyslipidemia, type 2 diabetes, and
fatty liver disease. Studies in human found FABP4 serum levels were significantly increased in overweight and obese subjects, which predicted the risk to develop metabolic syndrome and type 2 diabetes. Additionally, serum FABP4 levels were associated with
carotid atherosclerosis and coronary artery disease.
Purification
Rabbit crude IgG was purified by protein-G column.
Immunogen
Recombinant full-length human FABP4 expressed in E.coli.
Specificity
The antibody detects human FABP4.
Formulation
Liquid in phosphate-buffered saline (PBS).
Storage
Store at –20°C for less than one week. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.
Application/Usage
Western blot - This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect human FABP4.
Publications Cting This Product
1. Elie AG, Jensen PS, Nissen KD, Geraets IM, Xu A, Song E, Hansen ML, Irmukhamedov A, Rasmussen LM, Wang Y, De Mey JG. Adipokine imbalance in the pericardial cavity of cardiac and vascular disease patients. PloS one. 2016 May 3;11(5):e0154693.