Polyclonal Antibody against Human LCN2
Size: 0.1 mg
Introduction
Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), 24p3, or neutrophil lipocalin (NL), is a 25-kDa
secretory glycoprotein. LCN2 has been implicated in a variety of cellular processes including the innate immune response,
differentiation, tumorigenesis, and cell survival. It appears to be upregulated in various inflammation and infection conditions. Several reports suggest that LCN2 may represent a sensitive biomarker for various renal injuries and is associated with several types of
cancers, including breast cancer, ovarian, colorectal, and pancreatic cancers. Furthermore, a growing body of evidence suggests that serum levels of LCN2 are correlated with obesity, insulin resistance, coronary heart disease and fatty liver disease in humans.
Purification
Antigen affinity-purified
Immunogen
Recombinant full-length human LCN2 expressed in E.coli.
Specificity
The antibody detects circular human LCN2.
Formulation
Liquid in phosphate-buffered saline (PBS).
Storage
Store at –20°C for less than one week. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.
Application/Usage
Western blot and ELISA.
Publications Citing This Product
1. Ye D, Yang K, Zang S, Lin Z, Chau HT, Wang Y, Zhang J, Shi J, Xu A, Lin S, Wang Y. Lipocalin-2 mediates non-alcoholic steatohepatitis by promoting neutrophil-macrophage crosstalk via the induction of CXCR2. Journal of hepatology. 2016 Nov 1;65(5):988-97.
2. Song E, Jahng JW, Chong LP, Sung HK, Han M, Luo C, Wu D, Boo S, Hinz B, Cooper MA, Robertson AA. Lipocalin-2 induces NLRP3 inflammasome activation via HMGB1 induced TLR4 signaling in heart tissue of mice under pressure overload challenge. American journal of translational research. 2017;9(6):2723.
3. Ye D, Yang K, Zang S, Lin Z, Chau HT, Wang Y, Zhang J, Shi J, Xu A, Lin S, Wang Y. Corrigendum to “Lipocalin-2 mediates non-alcoholic steatohepatitis by promoting neutrophil-macrophage crosstalk via the induction of CXCR2”. Journal of hepatology. 2017 Mar 1;66(3):669.